The biochemical and molecular mechanisms involved in the role of tumor micro-environment stress in development of drug resistance

Lina Al-Akra,Dong-Hun Bae,Lionel Y.W. Leck,Des R. Richardson,Patric J. Jansson

Biochimica et Biophysica Acta (BBA) - General Subjects（2019）

引用 25|浏览8

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摘要

•Tumor microenvironment (TME) induce cancer progression, metastasis & drug resistance.•TME needs to be carefully addressed before the cancer can be treated successfully.•TME is a promising drug target for sensitizing the tumor to chemotherapeutics.

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关键词

Tumor micro-environment,Multi-drug resistance,Autophagy,Apoptosis,Metabolism,Hypoxia

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