AB0519 VITAMIN D CUT-OFF POINTS RELATED WITH CLINICAL FEATURES IN PATIENTSWITH ACTIVE LUPUS OR LUPUS NEPHRITIS

Background: Vitamin D (25OHD) has immunomodulatory properties that can play a major role in patients with active lupus or lupus nephritis. His immunomodulatory function could be influenced by demographic factors, comorbidities (Charlson score), bone supplements, and other features. Objectives: We explored the association between the best 25OHD cut-off points and specific clinical features that were present in patients with active lupus or lupus nephritis. Methods: A retrospective descriptive research using clinical registers of patients diagnosed with systemic erythematosus lupus, attended in two rheumatology clinics was performed. A decisions tree model was used to identify the best cut-off points of 25OHD [ng/mL] and clinical features associated with active lupus (SLEDAI-2k >6) or lupus nephritis. Results: We identified 81 patients, median age 41 years, women 91.3%. Active lupus and lupus nephritis were present in 69.1% and 29.6%, respectively. Median 25OHD was 26.49, without a difference at comparing with active lupus patients 24.85, but lower in lupus nephritis patients 21.50 (p: 0.015). Lupus nephritis was absent in patients with 25OHD cut-off points >38.8 (alone) or ≤38.8 if they were older than >57 years. Active lupus was always present in patients ≤44 years with 1. High comorbidity or 2. Low comorbidity plus cut-off point 25OHD >35; in >44 years, both a euthyroid state and the absence of bone supplements were present in patients with active lupus. Conclusion: Exist a strong relationship between vitamin D levels and LES activity. References [1] American College of Rheumatology. Guidelines for referral and management of systemic lupus erythematosus in adults. Arthritis Rheum. 1999 Sep;42(9):1785-96 [2] Simioni J, Heimovski F, Skare T. On lupus, vitamin D and leukopenia. 2016;56(3):206-211. [3] Guzman R.A, Pineros L.G, Theran A, Flechas J, Mejia M. AB0795 Hypovitaminosis D and Calcium Intake of Adult Population in Bogota (DICAVITD). Ann Rheum Dis 2016;75:1175-. 1176. Acknowledgement: To Fundacion Universitaria Juan N. Corpas Disclosure of Interests: None declared