AB0874 ANALYSIS OF LIFESTYLE AND CLINICAL FEATURES OF THE PATIENTS WITH GOUT IN MEIZHOU, GUANGDONG, CHINA

Background Gout is one of the most common metabolic diseases caused by purine metabolic disorder, leading to joint destruction and kidney impairment. With the improvement of living conditions, the incidence of gout is increasing year by year, especially in the developed coastal areas of China. Previous studies found that the management of gout was unsatisfied [1]. Besides, the development of rheumatology in Meizhou, Guangdong province is extremely slow. There are only ten rheumatologists, and the general public has a limited understanding of gout. Objectives Our aim was to explore the lifestyle, clinical features and risk factors of recurrent gout attacks in patients with gout in Meizhou, Guangdong province. Methods Demographic data, lifestyle and clinical data of 188 patients with gout in Meizhou were collected. Demographic variables included age, gender, marital status, education, BMI, smoking status, drinking status, diet, daily water intake, work style, exercise habit, late sleeping habit. Smoking status includes never smoking, ever-smoking or current smoking, and pack-year of smoking. The diet includes loving sweet food, beverage, seafood, fried food, and disliking vegetables and fruits. Amount of daily water intake is divided into 500-999ml, 1000-1499ml, 1500-1999ml and 2000ml and above. Working styles include long time of sitting, standing, walking, etc. Exercise habits include not exercising, exercising at least 1 hour a day, exercising at least 1 hour a week, and exercising at least 1 hour a month. Clinical characteristics include first time and cause of gout attack, blood uric acid value, the position of gout attack, pain score, duration, alleviating methods, treatment, patients’ self-reported gout episodes (below 5 times, 5-10 times, 11-20 times, more than 20 times), tophi, family history and comordities. Multiple regression analysis was used to analyze the factors of the numbers of gout attacks. Results: of the 188 cases, 171 (91.0%) were males and 17 (9.0%) were females. The average age was 55±16 years. 94 (50%) of the patients were drinking alcohol, and 58 (30.9%) were fond of seafood and other high-purine food. 149 (79.3%) patients had less than 1000ml of water per day, and the vast majority of patients had no exercise habit (136 (72.3%)). The interval between the first gout attack and the first uric acid increasing was -0.4 (S=2.5) years. The first gout attack occurred in the first metatarsophalangeal joint in 57 (30.3%) cases, followed by ankle jointa in 40 (21.3%) cases, knee jointa in 23 (12.2%) cases, and dorsal foot joints in 23 (12.2%) cases. The first gout attack occurred in 87 (46.3%) cases on the right side of the body. 25 (13.3%) patients’ first gout attack occurs in more than one joint. The number of tophus is 0∼21 per person. 64 (38.1%) patients had more than 20 gout attacks. Up to 70 (40.7%) patients never visited the hospital. 14 people were hospitalized due to gout. Colchicine was the most commonly used drug in treatment in 59 (31.4%) cases, followed by allopurinol in 49 (26.1%) cases. Gout was positively correlated with age (B=0.313, P=0.007) and uric acid (B=0.04, P=0.018). Conclusion Gout patients in Meizhou, Guangdong are mainly male, and have bad living habits such as drinking, loving hyper purine food and lack of drinking water and doing exercises. The first gout attack is more likely to involve a unilateral lower extremity, especially first metatarsophalangeal joints. Meizhou patients with gout have earlier occurrence of tophi, and fail to see a doctor and have medication regularly. Therefore, gout patients should develop good living habits and receive regular medical education. Reference [1] Li XM, Chen ZN, Gu JR. The current situation of hyperuricemia cannot be ignored [J]. New medicine,2016(03): 137-141 (in Chinese). Disclosure of Interests None declared