SAT0191 LOW SOCIOECONOMIC STATUS AND HEALTH RELATED QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Background: Socioeconomic factors have been considered as possible confounding factors in the attribution of greater damage accrual in Afro-Caribbean and Hispanic patients with Systemic lupus erythematosus (SLE). Patients with SLE often experience long-term morbidity that can adversely affect their health-related quality of life (HRQoL)1 Objectives: To analyze the relation between socioeconomic status, damage accrual and HRQoL Methods: Analytic study in a cohort of SLE patients that were closely monitored in an autoimmunity program in Colombia. We stratified patients with damage (SDI ≥1) and no damage (SDI Results: We analyzed 400 Colombian patients. Baseline median age was 49 years (15 IQR) with median age at diagnosis and disease duration of 37 years (17 IQR) and 9 years (13 IQR) respectively. There were 94% female patients and 17.3% late onset SLE. Most frequent clinical manifestations were hematological (82.8%), mucocutaneous (75.3%) and nephritis (33.8%). Only 4.5% had neurological involvement. The mean SLEDAI were 1.18 and 0.65 at first and second measurement respectively, in the first measurement 97.1% of the patients had a SLEDAI ≤4. The mean SDI was 0.7275 at first measurement and 0.985 at the second measurement. When comparing the intervention in patients with SDI≥1 there was a significative improvement in the Quotidian Activities, Pain/Discomfort, Anxiety/Depression domains, independent of economic income. In patients with medium-high income there was also a significative improvement in the mobility and personal care domains. In the no-damage groups there was only a positive impact in the Anxiety/Depression domain in a statistically significant manner, and the medium-high income subgroup had improvement in the Pain/Discomfort domain. We didn’t find other statistically differences in the other domains. Low economic income seems to exert a negative influence in the different HRQoL domains with independence regarding treatment strategy, specially in patients with no damage accrual. In patients with higher income and damage accrual the opposite seems to appear, which could be related with a better ability or resources to cope with the consequences of the disease Conclusion: In Colombian patients with SLE, socioeconomic status (as a reflection of income) might be related with HRQoL. This relationship could be influenced by damage accrual Reference [1] Panopalis P, Petri M, Manzi S, Isenberg DA, Gordon C, Senecal JL, et al, and the Tri-Nation Study Group. The systemic lupus erythematosus Tri-Nation study: cumulative indirect costs. Arthritis Rheum2007;57:64–70 Disclosure of Interests: None declared