Identification of anti-osteoclastogenic compounds from Cleistocalyx operculatus flower buds and their effects on RANKL-induced osteoclastogenesis

Phuong Thao Tran,Thi Quynh-Mai Ngo,Suhyun Lee,Okwha Kim,Huynh Nguyen Khanh Tran,Cheol Hwangbo,Byung Sun Min,Jeong-Hyung Lee

Journal of Functional Foods（2019）

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摘要

•The anti-osteoclastogenic effect of Cleistocalyx operculatus is demonstrated.•Ethanol extract of C. operculatus flower buds (ECB) inhibits RANKL-induced osteoclastogenesis.•Eight compounds are identified as anti-osteoclastogenic compounds from ECB.•Maslinic acid and its two coumaroyl analogs inhibit RANKL-induced NFATc1 activation.•The mechanism explains the anti-osteoclastogenic effect of C. operculatus flower buds.

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关键词

Cleistocalyx operculatus,Coumaroyl maslinic acid,Osteoclastogenesis,RANKL,NFATc1

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