SGLT2 Inhibitor-Induced Sympathoinhibition: A Novel Mechanism for Cardiorenal Protection.

•SGLT2 inhibitors improve cardiovascular outcomes.•SGLT2 inhibitor–induced sympathetic nervous system inhibition may be an underlying mechanism.•Chemical denervation in neurogenic hypertensive mice reduces renal SGLT2 expression.•SGLT2 inhibition lowered blood pressure and resulted in significantly reduced tyrosine hydroxylase and norepinephrine levels in the kidney tissue of neurogenic hypertensive mice.•Crosstalk between the sympathetic nervous system and SGLT2 regulation appears as a key mechanism of the cardiorenal protective effects demonstrated with SGLT2 inhibition.