Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.

•Activated microglia induced neuroinflammation in hippocampal CA1 and CA3 regions in mice.•Acetylated HMGB1 increased and mediated inflammation in hippocampal of mice after cold exposure.•Neuronal integrity in hippocampal CA1 and CA3 regions was destroyed after cold exposure.