Deletion of the thymidine kinase gene attenuates Caprine alphaherpesvirus 1 in goats.

Jéssica Caroline Gomes Noll,Lok Raj Joshi,Gabriela Mansano do Nascimento,Maureen Hoch Vieira Fernandes,Bishwas Sharma,Eduardo Furtado Flores,Diego Gustavo Diel

Veterinary Microbiology（2019）

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摘要

•Deletion of the tk gene from the CpHV-1 genome attenuates the virus in goats.•Traditional infection/transfection resulted in efficient CpHV-1 recombination.•Both parental and tk-deleted viruses established latency in neurons of the trigeminal ganglia.

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关键词

CpHV-1,Caprine viruses,Animal alphaherpesvirus,tk gene,Attenuation

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