Intraocular Metastasis in Unilateral Multifocal Uveal Melanoma Without Melanocytosis or Germline BAP1 Mutations

Scott D Walter
Scott D Walter
Manuel Paez-Escamilla
Manuel Paez-Escamilla
Julian Tokarev
Julian Tokarev
Amy C Schefler
Amy C Schefler

JAMA ophthalmology, 2019.

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Abstract:

Unilateral multifocal uveal melanoma in the absence of ocular melanocytosis appears to occur preferentially in tumors with the class 2 gene expression profile and a BRCA1-associated protein 1 gene (BAP1) mutation. The presence of identical BAP1 mutations in multiple tumors in the same eye in the absence of a germline BAP1 mutation suggest...More

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