Gray Matter Age Prediction as a Biomarker for Risk of Dementia

Johnny Wang
Johnny Wang
Maria J Knol
Maria J Knol
Aleksei Tiulpin
Aleksei Tiulpin
Florian Dubost
Florian Dubost
Gennady V Roshchupkin
Gennady V Roshchupkin

Proceedings of the National Academy of Sciences of the United States of America, pp. 2019023762019.

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Keywords:
age predictiondeep learningdementiamagnetic resonance imagingvoxel-based morphometry

Abstract:

The gap between predicted brain age using magnetic resonance imaging (MRI) and chronological age may serve as a biomarker for early-stage neurodegeneration. However, owing to the lack of large longitudinal studies, it has been challenging to validate this link. We aimed to investigate the utility of such a gap as a risk biomarker for inci...More

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