Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories.

Jaana Van Gastel,Huan Cai,Wei-Na Cong,Wayne Chadwick,Caitlin Daimon,Hanne Leysen,Jhana O Hendrickx,Robin De Schepper,Laura Vangenechten,Jens Van Turnhout,Jasper Verswyvel,Kevin G Becker,Yongqing Zhang,Elin Lehrmann,William H Wood,Bronwen Martin,Stuart Maudsley

Mechanisms of Ageing and Development（2019）

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摘要

•Across multiple species and diverse human cultures females demonstrate a longevity advantage.•GIT2 represents a keystone factor that controls somatic aging.•Genomic GIT2 heterozygosity induces a significant hypothalamic transcriptomic response.•Female GIT2 heterozygous mice demonstrate a stronger anti-aging response compared to males.

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关键词

GIT2,Longevity,Aging,Female,Hypothalamus

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