Identification and Characterization of an IgG Sequence Variant with an 11 Kda Heavy Chain C-terminal Extension Using a Combination of Mass Spectrometry and High-Throughput Sequencing Analysis.

Claire Harris,Weichen Xu,Luigi Grassi,Chunlei Wang, Abigail Markle,Colin Hardman, Richard Stevens,Guillermo Miro-Quesada,Diane Hatton,Jihong Wang

mAbs（2019）

引用 9|浏览9

关键词

Fc-extension,aberrant fusion protein,alternative splicing,high throughput sequencing,RT-PCR,monoclonal antibody,sequence variant,LC,MS,expression vector,splice variants,nanopore sequencing

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