Multifunctional REDV-G-TAT-G-NLS-Cys peptide sequence conjugated gene carriers to enhance gene transfection efficiency in endothelial cells.

•TP-G peptide was conjugated to amphiphilic copolymer to prepare gene carrier.•Their gene complexes exhibited high stability and targeting function for ECs.•The transfection efficiency, protein expression and EC migration were enhanced.•They are potential gene carriers for gene delivery in rapid endothelialization.