Novel Role of Tieg1 in Muscle Metabolism and Mitochondrial Oxidative Capacities.

Malek Kammoun,Jerome Piquereau,Lydie Nadal-Desbarats,Sandra Même,Maud Beuvin,Gisèle Bonne,Vladimir Veksler,Yann Le Fur,Philippe Pouletaut,William Même,Frederic Szeremeta,Jean-Marc Constans,Elizabeth S Bruinsma,Molly H Nelson Holte,Zeynab Najafova,Steven A Johnsen,Malayannan Subramaniam,John R Hawse,Sabine F Bensamoun

Acta physiologica (Oxford, England)（2020）

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摘要

Our findings have implicated novel roles for Tieg1 in muscle including regulation of gene expression, metabolic activity and organization of tissue ultrastructure. This muscle phenotype resembles diseases associated with exercise intolerance and myopathies of unknown consequence.

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关键词

Klf10 , Tieg1 ,Metabolism,Mitochondria,Skeletal Muscle

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