The Upregulation of OCT4 in Acidic Extracellular pH is Associated with Gemcitabine Resistance in Cholangiocarcinoma Cell Lines.

Phatchareeporn Choodetwattana,Siriporn Proungvitaya,Patcharee Jearanaikoon,Temduang Limpaiboon

Asian Pacific journal of cancer prevention : APJCP（2019）

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摘要

Our findings demonstrate that CCA cells can adapt to survive in acidic environment after which chemoresistance has been developed. Oct4 may be a key transcriptional regulator which mediates chemoresistance in response to acidic extracellular pH.

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关键词

Cancer stem cell-like cell,Chemoresistance,Liver cancer,Octamer-binding transcription factor 4,Tumor Microenvironment

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