Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo.

Cailing Gan,Yali Li,Yan Yu,Xi Yu,Hongyao Liu,Qianyu Zhang,Wenya Yin,Luoting Yu,Tinghong Ye

Bioorganic & Medicinal Chemistry（2019）

引用 12|浏览5

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摘要

•Pectolinarigenin could inhibit CRC cell growth and induce apoptosis.•Pectolinarigenin impaired CRC cell metastasis via MMPs signalling pathway.•Pectolinarigenin impaired CRC cell metastasis by down-regulating p-Stat3Tyr705.•Pectolinarigenin inhibit tumour metastasis by reducing the number of MDSCs cells.

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关键词

Colorectal cancer,Pectolinarigenin,Apoptosis,Metastasis,MDSCs

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