Interaction Between Sacubitril and Valsartan in Preventing Heart Failure Induced by Aortic Valve Insufficiency in Rats.

M Y Maslov,S Foianini, D Mayer,M V Orlov,M A Lovich

Journal of Cardiac Failure（2019）

引用 5|浏览6

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摘要

1) The synergistic interaction between NEPi and ARB in early therapy with sacubitril/valsartan leads to increased total arterial compliance and EF. 2) Improvement in indices of LV contractility, and exercise tolerance with sacubitril/valsartan is likely due to ARB effect of valsartan. 3) All three therapies provided antifibrotic effects, suggesting both ARB and NEPi are capable of reducing myocardial fibrosis.

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关键词

Sacubitril/valsartan,heart failure,aortic valve insufficiency,cardiac function,total arterial compliance

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