BDNF prevents central oxidative damage in a chronic unpredictable mild stress model: the possible role of PRDX-1 in anhedonic behavior.

Ellen Scotton,Rafael Colombo, Jéssica C Reis, Gabriela M P Possebon, Gabriel H Hizo,Fernanda E Valiati,Luiza P Géa,Giovana Bristot,Mirian Salvador,Tuani M Silva,Alessandra E Guerra,Tiago F Lopez,Adriane R Rosa,Maurício Kunz

Behavioural Brain Research（2020）

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摘要

•Increased BDNF levels, but no oxidative damage in the hippocampus from animal exposed to the CUMS.•Anhedonic rats show PRDX-1 up-regulation and RELA, ASK-1 and TAK-1 down-regulation.•BDNF and PRDX-1 may have a compensatory role and attenuate oxidative damage.

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关键词

Major depressive disorder,Anhedonic behavior,Chronic unpredictable mild stress,BDNF,Oxidative stress,Proteomics

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