Monosodium iodoacetate-induced monoarthritis develops differently in knee versus ankle joint in rats.

•Ankle versus knee joint injection of MIA in rats resulted in different behavioural profiles.•Levels of biochemical mediators differs between ankle and knee injection of MIA in rats.•Histopathological analysis show different results after ankle versus knee injection of MIA in rats.•The rat results mirror what has been found in human patients with osteoarthritis.