Nocebo in multiple sclerosis trials: A meta-analysis on oral and newer injectable disease-modifying treatments.
Multiple Sclerosis and Related Disorders(2019)
摘要
•Nocebo is linked to low adherence.•In MS trials nocebo is prevalent and increase by year of trial publication.•Nocebo is more frequent and more severe in oral DMTs than in newer injectables.•In RCTs with oral DMTs 8% of placebo treated patients withdrawn due to safety.•Treatment failure and intolerance may be partly powered by nocebo in MS practice.
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关键词
Multiple sclerosis,Disease-modifying treatments (DMTs),Nocebo,Placebo,Meta-analysis,Clinical trials
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