Targeted Sequencing Of Plasma Cell-Free Dna To Predict Response To Pd1 Inhibitors In Advanced Non-Small Cell Lung Cancer.

Nicolas Guibert,Greg Jones,John F. Beeler,Clive D. Morris,Vincent Plagnol,Jean Mourlanette,Myriam Delaunay,Isabelle Rouquette,Gilles Favre,Anne Pradines,Julien Mazieres

Lung Cancer（2019）

引用 68|浏览16

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摘要

•Targeted (36 genes) plasma NGS was performed in 86 patients treated with ICI.•Combination of molecular determinants of response to ICI can predict outcomes.•Early changes (1 month) in ctDNA burden also predict sustained responses.

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关键词

Next generation sequencing,Liquid biopsy,Circulating tumor DNA,Immunotherapy,PD-1 inhibitors,STK11,PTEN,Lung cancer

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