A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity.

Jingjing Ling,Ross W Cheloha,Nicholas McCaul,Zhen-Yu J Sun,Gerhard Wagner,Hidde L Ploegh

Molecular Immunology（2019）

引用 25|浏览18

暂无评分

摘要

•Identified single domain antibodies (VHHs) that bind to UBC6e with high affinity.•VHH binds to a short linear epitope near a phosphorylation site.•VHH binding to UBC6e enhances enzymatic activity.•VHH binding inhibits UBC6e phosphorylation in cells.

查看译文

关键词

Ubc6e,VHH,Single-domain antibody,Ubiquitin-conjugating enzyme (E2),Thioester,Ubiquitin,Phosphorylation,Endoplasmic reticulum associated degradation

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要