Deficiency of apoptosis-stimulating protein 2 of p53 protects mice from acute hepatic injury induced by CCl 4 via autophagy.

•During the development of acute hepatic injury, ASPP2 expression significantly upregulated at 24 h and 48 h after CCl4 injection.•ASPP2 haploid deletion protects mice from acute hepatic injury induce by CCl4.•ASPP2 haploid deletion inhibits inflammation and apoptosis in mice with acute hepatic injury induce by CCl4.•ASPP2 haploid deletion activates autophagy in mice with acute hepatic injury induce by CCl4.•ASPP2 haploid deletion protects mice from acute hepatic injury via autophagic activation.