TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex.

Minna Yli-Karjanmaa, Kathrine Solevad Larsen,Christina Dühring Fenger,Lotte Kellemann Kristensen,Nellie Anne Martin,Peter Toft Jensen,Alexandre Breton,Lubov Nathanson,Pernille Vinther Nielsen,Minna Christiansen Lund, Stephanie Lindeman Carlsen,Jan Bert Gramsbergen,Bente Finsen,Jane Stubbe,Lars Henrik Frich,Helen Stolp,Roberta Brambilla,Daniel Clive Anthony,Morten Meyer,Kate Lykke Lambertsen

Brain, Behavior, and Immunity（2019）

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摘要

•TNF deficiency alters the spatial organization of neurogenic zones.•TNF deficiency decreases WNT signaling-related proteins.•TNF deficiency alters neuronal and microglial numbers.•Long-term use of non-selective TNF inhibitors impairs learning and memory.•Long-term use of the soluble TNF selective inhibitor XPro1595 does not affect neurogenesis, learning and memory.

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关键词

Cytokines,Neurogenesis,TNF inhibitors

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