Duration of protection and humoral immunity induced by an adenovirus-vectored subunit vaccine for foot-and-mouth disease (FMD) in Holstein steers.

Tatjana Sitt,Mary Kenney,José Barrera, Mital Pandya,Korin Eckstrom, Megan Warner,Juan M Pacheco,Michael LaRocco,Javier Palarea-Albaladejo,David Brake,Elizabeth Rieder,Jonathan Arzt,John W Barlow,William T Golde

Vaccine（2019）

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摘要

•Vaccination with Adt.24 confers protection against FMD for six months.•Partial protection was demonstrated after six months.•Virus neutralizing titers do not correlate to protection.•Anti-FMDV antibody secreting cells are not detected in peripheral blood after 5 weeks following vaccination with Adt.A24.

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关键词

Foot-and-mouth disease virus,Cattle,Replication-deficient human adenovirus vectored vaccine,FMDV A24/Cruzeiro/BRA/55,Duration of protection,Humoral immunity

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