High performance of rapid influenza diagnostic test and variable effectiveness of influenza vaccines in Mexico.

•RIDT showed a high performance to detect influenza cases during an outbreak setting.•Effectiveness of influenza vaccines administered in Mexico City was low but significant.•Quadrivalent vaccine effectiveness for influenza B was higher than trivalent vaccine.•Influenza A(H1N1)pdm09 virus was the predominant strain in our study.•Immunization and occupational exposure are protective factors against influenza.