Delayed GALT reconstitution in duodenum compared to rectum in hiv-infected patients initiating antiretroviral therapy.

Talia Sainz, Sergio Serrano-Villar,Surinder Mann,Zhong-Min Ma, Netanya S Utay,Corbin G Thompson, Tae-Wook Chun,Angela D Kashuba, Basile Siewe,Anthony Albanese, Paolo Troia-Cancio, Elizabeth Sinclair,Anoma Somasunderam, Tammy Yotter,Santiago Moreno, Richard B Pollard,Alan Landay, Christopher J Miller,David M Asmuth

AIDS (London, England)（2019）

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摘要

HIV-mediated immunological disruption is greater in the duodenum than rectum and blood before and during ART. Small intestine damage may represent a unique environment for T-cell depletion, which might be attenuated by interaction with gram positive bacteria.

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