MTDH/AEG-1 downregulation using pristimerin-loaded nanoparticles inhibits Fanconi anemia proteins and increases sensitivity to platinum-based chemotherapy.

Jianling Bi,Sudartip Areecheewakul,Yujun Li,Shujie Yang,Yuping Zhang,Kareem Ebeid,Long Li,Kristina W Thiel,Jun Zhang,Donghai Dai,Aliasger K Salem,Kimberly K Leslie,Xiangbing Meng

Gynecologic Oncology（2019）

引用 17|浏览21

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摘要

•Endometrial cancer patients with high copy number of MTDH show poor outcome.•Inhibition MTDH increases DNA damage induced γ-H2Ax foci formation and sensitivity to cisplatin.•MTDH binds with mRNAs encoding for FANCD2 and FANCI.•Pristimerin-loaded nanoparticles inhibit MTDH, FANCD2 and FANCI to increase sensitivity to cisplatin.

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关键词

MTDH,FANCD2,FANCI,Pristimerin,Cisplatin,Nanoparticles

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