Yield of Lynch Syndrome Surveillance for Patients With Pathogenic Variants in DNA Mismatch Repair Genes.

A Goverde, E L Eikenboom, E L Viskil,M J Bruno,M Doukas,W N M Dinjens,H J Dubbink,A M W van den Ouweland,R M W Hofstra,A Wagner,M C W Spaander

Clinical Gastroenterology and Hepatology（2020）

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摘要

No CRC was found during follow-up of patients with Lynch syndrome carrying pathogenic variants in MSH6; advanced neoplasia developed over shorter follow-up time periods in patients with pathogenic variants in MLH1 or MSH2. The colonoscopy interval for patients with pathogenic variants in MSH6 might be increased to 3 years from the regular 2-year interval.

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Hereditary Cancer Prevention,Genetics,MMR,Colon

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