Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of EGFR-dependent Serrated Polyps in Mouse Cecum.

In studies of mice, we found that barrier breakdown and expression of inflammatory factors contribute to development of serrated polyps. Subsets of cecal PDGFRA-positive fibroblasts are activated by release of IL1B from myeloid cells during early stages of serrated polyp development. MMP3 produced by PDGFRA-positive fibroblasts is important for serrated polyp development. Our findings confirm the functions of previously identified serrated polyp-associated molecules, and indicate roles for immune and stromal cells in serrated polyp development.