Biocatalytic Synthesis of Non-Natural Monoterpene O -Glycosides Exhibiting Superior Antibacterial and Antinematodal Properties.

A promiscuous glycosyltransferase (YjiC) was explored for the enzymatic synthesis of monoterpene -glycosides in vitro and in vivo. YjiC converted seven monoterpenes into 41 different sugar-conjugated novel glycoside derivatives. The whole-cell biotransformation of the same set of monoterpenes exhibited robust enzyme activity to synthesize -glucosyl derivatives from . These newly synthesized selected monoterpene--glucosyl derivatives exhibited enhanced antibacterial activities against human pathogenic bacteria and antinematodal activities against pine wood nematode .