Imbalance between nitric oxide and superoxide anion induced by uncoupled nitric oxide synthase contributes to human melanoma development.

Diego Assis Gonçalves,Ricardo Xisto,Jéssica Domingues Gonçalves,Douglas Baceti da Silva, Jaqueline Pereira Moura Soares,Marcelo Yudi Icimoto, Carla Sant'Anna,Marcela Gimenez,Kátia de Angelis,Susana Llesuy,Denise C Fernandes,Francisco Laurindo,Miriam Galvonas Jasiulionis,Fabiana Henriques Machado de Melo

The International Journal of Biochemistry & Cell Biology（2019）

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摘要

•Increased superoxide anion and decreased nitric oxide levels in metastatic human melanoma cells.•Decreased BH4:BH2 ratio in metastatic human melanoma cells.•Stoichiometric imbalance between BH4 and NOS in metastatic human melanoma cells contributing to NOS uncoupling and melanoma progression.

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关键词

NOS,ROS,BH4,BH3,BH2,GTPCHI,UV

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