Expression Of Delta-Like Protein 3 Is Reproducibly Present In A Subset Of Small Cell Lung Carcinomas And Pulmonary Carcinoid Tumors
MODERN PATHOLOGY(2019)
摘要
•Interobserver agreement for DLL3 expression is substantial among thoracic pathologists.•High DLL3 expression (≥ 50% of tumor cells) is observed in almost 80% of small cell lung carcinomas.•Approximately one third of atypical and typical carcinoid tumors show high DLL3 expression.•High DLL3 expression is associated with better overall survival in small cell lung carcinomas.
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关键词
Carcinoid tumors,Small cell lung cancer,DLL3,Rovalpituzumab tesirine
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