An Italian multicentre study of perampanel in progressive myoclonus epilepsies.

•Forty-nine patients with progressive myoclonus epilepsy took perampanel in add-on.•Perampanel reduced myoclonus severity as assessed by minimal myoclonus scale.•Action myoclonus improved greatly as measured by the unified myoclonus rating scale.•Convulsive seizures were reduced by >50%.•Side effects occurred in 44.8% patients, the most common being irritability.