Effect of Mycoplasma bovis on expression of inflammatory cytokines and matrix metalloproteinases mRNA in bovine synovial cells.

Koji Nishi,Satoshi Gondaira,Mariko Okamoto,Takanori Nebu,Masateru Koiwa,Hiromichi Ohtsuka,Kiyokazu Murai,Kazuya Matsuda,Jumpei Fujiki,Hidetomo Iwano,Hajime Nagahata,Hidetoshi Higuchi

Veterinary Immunology and Immunopathology（2019）

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摘要

•The expression of inflammatory cytokines and MMPs mRNA in synovial tissue was higher in MA calves.•M. bovis induces inflammatory cytokines and MMPs in synovial cells.•Mononuclear cells have a key role to induce mRNA expression of cytokines and MMPs of synovial cells stimulated with M. bovis.

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关键词

MA,MMPs,TIMPs,ECM,SF,stm-supernatant,unstm-supernatant

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