Genomic Landscape and Immune Microenvironment Features of Preinvasive and Early-Invasive Lung Adenocarcinoma.
Journal of Thoracic Oncology(2019)
摘要
Mutations in EGFR, ERBB2, NRAS and BRAF are early clonal genomic events during carcinogenesis of lung adenocarcinoma while TP53 and cell mobility, gap junction and metastasis-related genes may be late events associated with subclonal diversification and neoplastic progression. Genomic ITH and immunoediting are common and early phenomena that may have occurred before the acquisition of invasion.
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关键词
Lung adenocarcinoma,Whole exome sequencing,Genomic evolution,Pathological subtypes
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