Synthesis and characterization of novel isoform-selective IP6K1 inhibitors.

Michael M Wormald,Glen Ernst,Huijun Wei,James C Barrow

Bioorganic & Medicinal Chemistry Letters（2019）

引用 12|浏览11

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摘要

•Structure-activity relationships based on a non-selective lead revealed compound 24 as a selective inhibitor of IP6K1.•Compound 24 has good selectivity over closely related kinases IP6K2 and IP6K3 as well as a panel of other diverse kinases.•Compound 24 is a useful tool to investigate the role of IP6K1 selective inhibitors.

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关键词

Inositol hexakisphosphate kinase,Inositol pyrophosphate,Selective enzyme inhibitors,Structure activity relationships,Kinases

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