Amino acid changes in HA and determinants of pathogenicity associated with influenza virus A H1N1pdm09 during the winter seasons 2015-2016 and 2016-2017 in Mexico.

Joel Armando Vázquez-Pérez,Daniela De La Rosa-Zamboni,Ángel Emmanuel Vega-Sánchez,Luis Horacio Gutiérrez-González,Norma Angélica Téllez-Navarrete,Fernando Campos,Cristóbal Guadarrama-Pérez, José Luis Sandoval,Manuel Castillejos-López,Rodolfo Norberto Jiménez-Juárez,José Luis Sánchez-Huerta,Brenda Berenice Pérez-Méndez,Rogelio Pérez-Padilla

Virus Research（2019）

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摘要

•H1N1pdm09 belonging to clade 6B.1 instead of H3N2 were detected in Mexico in 2017.•A new glycosylation site in HA (S162 N) may affect the efficacy of the current vaccine.•The new insertion Ile113 in NS1 may strengthen the interaction with CPSF30.

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关键词

Influenza virus,AH1N1pdm09,Pathogenicity,Molecular determinants

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