Synthesis of the Dynamical Properties of Feedback Loops in Bio-pathways.

IEEE/ACM Transactions on Computational Biology and Bioinformatics(2021)

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摘要
Feedback loops regulate various biological functions such as oscillations, bistability, and robustness. They play a significant role in developmental signalling and failure of feedback can lead to disease. Systematic analysis of feedback loops could be useful in understanding their properties and biological effects. We propose here a method to automatically analyze feedback loops in bio-pathways a...
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关键词
Biological system modeling,Negative feedback loops,Trajectory,Mathematical model,Oscillators
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