Tuberculosis vaccination sequence effect on protection in wild boar.

Iratxe Díez-Delgado,Iker A Sevilla,Joseba M Garrido,Beatriz Romero,María V Geijo,Lucas Dominguez,Ramón A Juste,Alicia Aranaz,José de la Fuente,Christian Gortazar

Comparative Immunology, Microbiology and Infectious Diseases（2019）

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摘要

•Homologous IV and BCG vaccination and heterologous IV-BCG vaccination in wild boar reduce TB lesion scores.•IV-BCG vaccination reduces TB lesion scores but BCG-IV vaccination confers no protection.•Vaccine sequence dramatically influences the outcome of TB vaccination.•Homologous IV regime is the most practical option to vaccinate wild boar against TB.•Sensitization status against mycobacteria needs to be considered before vaccination.

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关键词

Animal tuberculosis,BCG,Heat-inactivated Mycobacterium bovis,Heterologous prime-boost,Laboratory vaccination and challenge experiment,Sus scrofa.

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