Differences between planned and delivered dose for head and neck cancer, and their consequences for normal tissue complication probability and treatment adaptation.

Jolien Heukelom,Michael E Kantor,Abdallah S R Mohamed,Hesham Elhalawani,Esengul Kocak-Uzel, Timothy Lin,Jinzhong Yang,Michalis Aristophanous,Coen R Rasch,Clifton David Fuller,Jan-Jakob Sonke

Radiotherapy and Oncology（2020）

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摘要

•Delivered-planned dose differences were quantified with daily CT-on-Rails.•Considerable dose differences were observed in 17% of HNSCC patients.•These dose differences changed normal tissue complication probability (ΔNTCP) >5%.•ΔNTCP can identify patients for adaptive radiotherapy better than clinical judgement.

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关键词

Head and neck cancer,Radiotherapy,Dose-summation,NTCP,ART

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