Availability of a simplified lung ventilation imaging algorithm based on four-dimensional computed tomography.

•We propose a simplified algorithm, VIAAVG, which is independent on DIR and requires only AVG CT as input.•Accuracy and efficiency are evaluated for 50 patients, which is the largest cohort as far as we know.•VIAAVG shows nearly substantial similarity with gold standard, VISPECT, which is higher than other proposed algorithms.•VIAAVG takes much less time to compute CTVI than other algorithms proposed before.•VIAAVG is more convenient for clinical use, since structures, dose, lung function are all defined on the same AVG CT.