Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.

•Design, synthesis and biological evaluation of novel COX-2 selective inhibitors.•COX-2 inhibitors are efficacious as analgesic agents in vivo.•In silico studies highlight the binding mode of the compounds into COX-2 enzyme.