Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis.

Katalin Módis, V-M Sadagopa Ramanujam,Armita Abdollahi Govar,Ernesto Lopez,Karl E Anderson,Rui Wang,Csaba Szabo

Biochemical Pharmacology（2019）

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摘要

The CSE system regulates the expression of CPOX and consequent heme synthesis. These effects in turn, do not influence global oxygen transport parameters, but may regulate mitochondrial electron transport.

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关键词

ADP,ATP,AUC,AzMc,2,3-DPG,FCCP,CPOX,CBS,CSE,DMEM,ETC,EPO,GAPDH,HPLC,H2S,MCV,3-MST,TMPD,PLP,RBC,TST,OXPHOS,UROD

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