Tetravalent Metal Ion Guests In Polyoxopalladate Chemistry: Synthesis And Anticancer Activity Of [Mo8pd12(Po4)(8)](12-) (M = Sn-Iv, Pb-Iv)

The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)(8)](12-) (M = Sn-IV, Pb-IV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.