The Relative Role of CYP3A4 and CYP3A5 in Eplerenone Metabolism.

Joseph McGraw, Mitchell Cherney, Katherine Bichler, Armin Gerhardt,Mirielle Nauman

Toxicology Letters（2019）

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摘要

Eplerenone is metabolized to 6β-hydroxyeplerenone specifically via CYP3A4 while the 21-hydroxy metabolite is generated via both CYP3A4 and CYP3A5.

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关键词

ACN,APCI,CE,CXP,Clint,CYP450,DP,fm,HLM,IC50,ISEF,KM,K3PO4,MRM,MS,m.w.,NADPH,rhCYP,UHPLC,USP,Vmax

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