Efficacy of Novel Bromodomain and Extraterminal Inhibitors in Combination with Chemotherapy for Castration-Resistant Prostate Cancer

Ramiro Vázquez,Gianluca Civenni,Aleksandra Kokanovic,Dheeraj Shinde, Jasmine Cantergiani,Martina Marchetti,Giada Zoppi,Bruce Ruggeri,Phillip C C Liu,Giuseppina M Carbone,Carlo V Catapano

European Urology Oncology（2021）

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摘要

Chemotherapy has limited impact in patients with advanced castration-resistant prostate cancer (CRPC). This study demonstrates the enhanced antitumor efficacy of docetaxel, olaparib, and carboplatin when combined with the bromodomain and extraterminal inhibitor INCB057643, encouraging clinical evaluation of this strategy in advanced CRPC nonresponsive to androgen receptor–targeted therapies.

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关键词

Prostate cancer,Castration-resistant prostate cancer,Bromodomain inhibitors,INCB054329,INCB057643,Docetaxel,Olaparib,Carboplatin

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