Membrane tension regulates syndecan-1 expression through actin remodelling.

Biochimica et Biophysica Acta (BBA) - General Subjects（2019）

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摘要

•Membrane tension increased by hypo-osmotic stress reduces syndecan-1 expression.•The reduction of syndecan-1 is transient and associated with actin depolymerisation.•Ions and glucose do not interfere with the osmoregulation of syndecan-1.•Depolymerising actin maintains syndecan-1 at a reduced level, whereas stabilisation of the actin suppresses the reduction.

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关键词

Endothelial glycocalyx,Cytoskeleton,Hypo-osmotic stress,Vascular biology

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