Epidemiology and characterisation of carbapenem-non-susceptible Pseudomonas aeruginosa in a large intensive care unit in Jakarta, Indonesia

Yulia Rosa Saharman,Andreu Coello Pelegrin,Anis Karuniawati,Rudyanto Sedono,Dita Aditianingsih,Wil H.F. Goessens,Corné H.W. Klaassen,Alex van Belkum,Caroline Mirande,Henri A. Verbrugh,Juliëtte A. Severin

International Journal of Antimicrobial Agents（2019）

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摘要

•Carbapenem-non-susceptible P. aeruginosa (CNPA) were found to be endemic in a large referral hospital in Indonesia.•Acquisition of CNPA was associated with significantly longer ICU length of stay.•Carriage of CNPA may affect ICU survival.•Carbapenem-non-susceptibility among P. aeruginosa is largely due to IMP, VIM and GES-5 carbapenemases.•Most CNPA isolates belonged to the international clones ST235, ST357, ST446 and ST823.

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关键词

Pseudomonas aeruginosa,Microbial drug resistance,Carbapenemase,Metallo-β-lactamase,Intensive care unit,Indonesia

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