Optimal vancomycin dosing regimens for critically ill patients with acute kidney injury during continuous renal replacement therapy: A Monte Carlo simulation study

•No current literature-based vancomycin dosing regimens achieved the 90% of the PTA target•1.75 g every 24 h were recommended for MRSA infection with MIC ≤1 mg/L for CRRT with effluent flow rate of 20 mL/kg/h•Higher effluent flow rate required higher vancomycin dosing regimens•Alternative drugs for treatment of MRSA infection with vancomycin MIC >1 mg/L should be considered